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62996-74-1 - Staurosporine, 99+% - Antibiotic AM-2282 - J62837 - Alfa Aesar

J62837 Staurosporine, 99+%

CAS Number
62996-74-1
Synonyms
Antibiotic AM-2282

Size Price ($) Quantity Availability
1mg 113.00
5mg 295.00
10mg 549.00
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Staurosporine, 99+%

MDL
MFCD00077402

Chemical Properties

Formula
C28H26N4O3
Formula Weight
466.54
Form
Powder
Melting point
240-243°
Solubility
Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.

Applications

Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.

Notes

Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Kohno, T.; Ninomiya, T.; Kikuchi, S.; Konno, T.; Kojima, T. Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts. Mol. Pharmacol. 2015, 87 (5), 815-824.

Lee, H. G.; Kim, D. S.; Moon, S. A.; Kang, J. W.; Seo, J. T. Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes. Int. J. Oral Biol. 2015, 40 (1), 27-33.

GHS Hazard and Precautionary Statements

Hazard Statements: H350

May cause cancer.

Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8802
Beilstein
1060573
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
KD5084000

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