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Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.
Kohno, T.; Ninomiya, T.; Kikuchi, S.; Konno, T.; Kojima, T. Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts. Mol. Pharmacol. 2015, 87 (5), 815-824.
Lee, H. G.; Kim, D. S.; Moon, S. A.; Kang, J. W.; Seo, J. T. Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes. Int. J. Oral Biol. 2015, 40 (1), 27-33.
Hazard Statements: H350
May cause cancer.
Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.