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67526-95-8 - Thapsigargin, 95% - J62866 - Alfa Aesar

J62866 Thapsigargin, 95%

CAS Number
67526-95-8
Synonyms

Size Price ($) Quantity Availability
1mg 91.67
5mg 304.00
10mg 672.59
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Thapsigargin, 95%

MDL
MFCD00083511

Chemical Properties

Formula
C34H50O12
Formula Weight
650.75
Form
Solid film
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.

Applications

Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C.

Literature References

Davidson and Varhol. Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition. J.Biol.Chem. 1995, 270 (20), 11731-4.

Treiman et al. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. TiPS . 1998, 19 (4), 131-5.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9272
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
RH0325700

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