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120685-11-2 - Midostaurin - PKC412 - 4'-N-Benzoylstaurosporine - J62917 - Alfa Aesar

J62917 Midostaurin

CAS Number
120685-11-2
Synonyms
PKC412
4'-N-Benzoylstaurosporine

Size Price ($) Quantity Availability
1mg 108.00
5mg 395.00
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Midostaurin

MDL
MFCD12828879

Chemical Properties

Formula
C35H30N4O4
Formula Weight
570.64
Form
Powder
Melting point
235-260°
Solubility
Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).

Applications

Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from Strong acids, oxidizing agents, bases.

Literature References

Fabbro et al. PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 200015 (1), 17-28.

Tenzer et al. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 200161 (22), 8203-10.

Other References

Merck
14,6185
Harmonized Tariff Code
2934.99
TSCA
No

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