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9009-65-8 - Protamine sulfate - J62926 - Alfa Aesar

J62926 Protamine sulfate

CAS Number
9009-65-8
Synonyms

Size Price ($) Quantity Availability
1g 34.40
5g 94.00
10g 163.00
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Protamine sulfate

MDL
MFCD00132091

Chemical Properties

Form
Powder
Sensitivity
Hygroscopic
Solubility
It is sparingly soluble in water.

Applications

It is suitable for personal care, cosmetic and pharmaceutical applications. It is used widely to reverse the anticoagulant effects of heparin. It acts as a heparin antagonist. It is also a weak anticoagulant. It may be used for the removal of DNA from protein samples or the purification of DNA binding proteins. Protamine sulfate may also be used as an alternative to polybrene in retroviral mediated gene transfer. Protamine sulfate has antibacterial properties and inhibits pepsin activity. Protamine sulfate and other polycations have been shown to inhibit the classical pathway of complement. It neutralizes the anticoagulant activity of heparin, and inhibits turnover of lipoproteins by lipoprotein lipase. The aggregation of erythrocytes in the presence of protamine sulfate, for application to the prediction of MN phenotypes, has been investigated.

Notes

Hygroscopic. Store at room temperature. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

Kenneth Cornetta.; W.French Anderson. Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy. Journal of Virological Methods. 1989, 23, (2), 187-194.

Sorgi, FL.; Bhattacharya, S.; Huang, L. Protamine sulfate enhances lipid-mediated gene transfer. Gene therapy . 1997, 4, (9), 961-8.

Other References

Harmonized Tariff Code
3504.00
TSCA
Yes
RTECS
UK9450000

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