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7059-24-7 - Chromomycin A3, 97% - J62927 - Alfa Aesar

J62927 Chromomycin A3, 97%

CAS Number
7059-24-7
Synonyms

Size Price ($) Quantity Availability
10mg 307.00
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Chromomycin A3, 97%

MDL
MFCD00043151
EINECS
230-348-0

Chemical Properties

Formula
C57H82O26
Formula Weight
1183.30
Form
Powder
Melting point
185° dec.
Solubility
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).

Applications

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

CT Amemiya.;JR Gold. Chromomycin A3 stains nucleolus organizer regions of fish chromosomes. Copeia. 19861986 (1), 226-231.

RH Jensen. Chromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples. Journal of Histochemistry & Cytochemistry. 197725 (7), 573-579.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H360

Fatal if swallowed. May damage fertility or the unborn child.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2238
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
GB7875000

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