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Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.
CT Amemiya.;JR Gold. Chromomycin A3 stains nucleolus organizer regions of fish chromosomes. Copeia. 19861986 (1), 226-231.
RH Jensen. Chromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples. Journal of Histochemistry & Cytochemistry. 197725 (7), 573-579.
Hazard Statements: H300-H360
Fatal if swallowed. May damage fertility or the unborn child.
Precautionary Statements: P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant