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66701-25-5 - E-64 - trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane - J62933 - Alfa Aesar

J62933 E-64

CAS Number
66701-25-5
Synonyms
trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

Size Price ($) Quantity Availability
5mg 96.40
25mg 401.00
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E-64

MDL
MFCD00080261

Chemical Properties

Formula
C15H27N5O5
Formula Weight
357.40
Form
Powder
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO (25mg/ml), or water (20mg/ml)

Applications

It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.

Literature References

Susa et al. Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay. J.Transl.Med. 2004, 2, (1), 6-9.

Zhao et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat.Cell.Biol. 2010, 12, (7), 665-75.

Other References

Beilstein
1405664
Harmonized Tariff Code
2925.29
TSCA
No
RTECS
RR0390000

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