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79645-27-5 - Tobramycin sulfate - J62995 - Alfa Aesar

J62995 Tobramycin sulfate

CAS Number
79645-27-5
Synonyms

Size Price ($) Quantity Availability
100mg 42.60
1g 280.00
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Tobramycin sulfate

MDL
MFCD00133864

Chemical Properties

Formula
(C18H37N5O9)2•5H2SO4
Formula Weight
1425.41
Form
Powder
Solubility
Soluble in water (50 mg/ml).

Applications

Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

Alhariri M & Omri A. Efficacy of liposomal bismuth-ethanedithiol-loaded tobramycin after intratracheal administration in rats with pulmonary Pseudomonas aeruginosa infection. Antimicrob Agents Chemother.2013, 57, (1), 569-78.

Li M & Byron PR Tobramycin disposition in the rat lung following airway administration. J Pharmacol Exp Ther.2013, 347, (2), 318-24.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9490
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
WK2110000

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