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52665-69-7 - Antibiotic A23187, 98% - Calcimycin - Calcium ionophore A23187 - J63020 - Alfa Aesar

J63020 Antibiotic A23187, 98%

CAS Number
52665-69-7
Synonyms
Calcimycin
Calcium ionophore A23187

Size Price ($) Quantity Availability
10mg 131.00
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Antibiotic A23187, 98%

MDL
MFCD00151202
EINECS
258-084-1

Chemical Properties

Formula
C29H37N3O6
Formula Weight
523.62
Form
Powder
Solubility
Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate

Applications

A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ~ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Literature References

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem.2007, 282, (7), 4702-10 .

Kajitani et al. Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase. Biosci.Biotechnol.Bichem.2007, 22, (4), 888-93.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1639
Beilstein
1096801
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
DM4676000

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