Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

738-70-5 - Trimethoprim - 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine - J63053 - Alfa Aesar

J63053 Trimethoprim

CAS Number
738-70-5
Synonyms
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Size Price ($) Quantity Availability
1g 26.06
5g 69.63
25g 278.10
Add to Cart Add to Quote Request View Item

Trimethoprim

MDL
MFCD00036761
EINECS
212-006-2

Chemical Properties

Formula
C14H18N4O3
Formula Weight
290.32
Form
Powder
Melting point
199-203°
Solubility
Trimethoprim is soluble in water at 0.4 mg/ml. It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml. Soluble in methanol, chloroform, dimethyl sulfoxide, N,N-dimethylacetamide, benzyl alcohol, and propylene glycol. Insoluble in water, diethyl ether and benzene.

Applications

An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and traveler’s diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.

Notes

Sensitive to light. Incompatible with strong oxidizing agents. Sore in a cool place.

Literature References

Moreira, F. C.; Boaventura, R. A.; Brillas, E.; Vilar, V. J. Degradation of trimethoprim antibiotic by UVA photoelectro-Fenton process mediated by Fe(III)-carboxylate complexes. Appl. Catal., B 2015, 162, 34-44.

Felix, J. P. F.; Lira, R. P. C.; Zacchia, R. S.; Toribio, J. M.; Nascimento, M. A.; Arieta, C. E. L. Trimethoprim-sulfamethoxazole versus placebo to reduce the risk of recurrences of Toxoplasma gondii retinochoroiditis: randomized controlled clinical trial. Am. J. Ophthalmol. 2014, 157 (4), 762-766.

Other References

Merck
14,9709
Beilstein
625127
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UV8225000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware