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138977-28-3 - Capsazepine, 99+% - J63055 - Alfa Aesar

J63055 Capsazepine, 99+%

CAS Number
138977-28-3
Synonyms

Size Price ($) Quantity Availability
10mg 150.38
50mg 541.80
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Capsazepine, 99+%

MDL
MFCD00153778

Chemical Properties

Formula
C19H21ClN2O2S
Formula Weight
376.90
Form
Powder
Melting point
159-161°
Solubility
Soluble in ethanol or DMSO

Applications

Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Literature References

Dickenson and Dray. Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br.J.Pharmacol. 1991, 104, (4), 1045-9.

Kwak et al. A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience. 1998, 86, (2), 619-26.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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