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951-77-9 - 2'-Deoxycytidine - J63062 - Alfa Aesar

J63062 2'-Deoxycytidine

CAS Number
951-77-9
Synonyms

Size Price ($) Quantity Availability
1g 23.18
5g 69.42
25g 242.10
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2'-Deoxycytidine

MDL
MFCD00006547
EINECS
213-454-1

Chemical Properties

Formula
C9H13N3O4
Formula Weight
227.22
Form
Crystalline powder
Melting point
209-211°
Solubility
Soluble in water, DMSO.

Applications

2?-Deoxycytidine (deoxyC) is one of the deoxynucleosides which after phosphorylation to dCTP is used to synthesis DNA via various DNA polymerases or reverse transcriptases. 2?-Deoxycytidine (deoxyC) is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2?-deoxyuridine. 2?-Deoxycytidine is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK).

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents. Stable under recommended storage conditions.

Literature References

JK Christman. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 200221 (35), 5483-5495.

LW Herte.; GB Boder.; JS Kroin.; SM Rinzel, GA Poore. Evaluation of the antitumor activity of gemcitabine (2?, 2?-difluoro-2?-deoxycytidine). Cancer research. 199050 (1), 4417-4419.

Other References

Beilstein
87567
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
HA3800000

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