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59-05-2 - Methotrexate - J63075 - Alfa Aesar

J63075 Methotrexate

CAS Number
59-05-2
Synonyms

Size Price ($) Quantity Availability
100mg 113.30
1g 576.80
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Methotrexate

MDL
MFCD00150847
EINECS
200-413-8

Chemical Properties

Formula
C20H22N8O5
Formula Weight
454.44
Form
Powder
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Applications

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Literature References

Allegra et al. Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 1987, 262, (28), 13520-6.

Cronstein, B. N. Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews . 2005, 57, (2), 163-172.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H360

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May damage fertility or the unborn child.

Precautionary Statements: P201-P280-P281-P301+P310-P305+P351+P338-P362-P308+P313-P321-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5985
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
Yes
RTECS
MA1225000

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