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90729-43-4 - Ebastine - J63088 - Alfa Aesar

J63088 Ebastine

CAS Number
90729-43-4
Synonyms

Size Price ($) Quantity Availability
1g 129.78
5g 406.46
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Ebastine

MDL
MFCD00865661

Chemical Properties

Formula
C32H39NO2
Formula Weight
469.66
Form
Powder
Melting point
84-87°
Solubility
Slightly soluble in chloroform, methanol.

Applications

Ebastine is a second-generation H1 receptor antagonist that is indicated mainly for allergic rhinitis and chronic idiopathic urticaria. It is available in 10 and 20 mg tablets and as fast-dissolving tablets, as well as in pediatric syrup. It has a recommended flexible daily dose of 10 or 20 mg, depending on disease severity.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Tagawa, M; Kano, M; Okamura, N (2001). Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-clorphrniramine, a classical antihistamine. Br J Clin Pharmacol. 197752 (5), 501-509.

Bousquet, J; Gaudaño, EM; Palama Carlos, AG. A 12-week, placebo-controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis. Allergy. 199954 (6), 562-568.

Other References

Merck
14,3484
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
EL8140000

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