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A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.
Nguyen, M. A.; Staubach, P.; Tamai, I.; Langguth, P. High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. Eur. J. Pharm. Sci. 2015, 68, 36-42.
Pai, D. A.; Vangala, V. R.; Ng, J. W.; Ng, W. K.; Tan, R. B. H. Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization. J. Food Eng. 2015, 161, 68-74.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.