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15686-71-2 - Cephalexin hydrate, 97+% - J63172 - Alfa Aesar

J63172 Cephalexin hydrate, 97+%

CAS Number
15686-71-2
Synonyms

Size Price ($) Quantity Availability
5g 57.89
25g 213.00
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Cephalexin hydrate, 97+%

MDL
MFCD00167148
EINECS
239-773-6

Chemical Properties

Formula
C16H17N3O4S•xH2O
Formula Weight
347.39(anhy)
Form
Powder
Solubility
Soluble in DMSO and Methanol.

Applications

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Tomoko Sugiura et. al. PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice. Drug Metabolism and Disposition. 200836 (6), 1181-1188.

Karolina Langowska et. al. Polymer nanoreactors shown to produce and release antibiotics locally. Chemical Communications. 201349 (2), 128-130 .

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H317

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Precautionary Statements: P285-P261-P280-P342+P311-P363-P304+P341-P321-P333+P313-P302+P352-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1974
Beilstein
965503
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
XI0350000

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