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59865-13-3 - Cyclosporin A, 99+% - Cyclosporine A - Antibiotic S 7481F1 - J63191 - Alfa Aesar

J63191 Cyclosporin A, 99+%

CAS Number
59865-13-3
Synonyms
Cyclosporine A
Antibiotic S 7481F1

Size Price ($) Quantity Availability
1g 171.00
5g 377.00
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Cyclosporin A, 99+%

MDL
MFCD00274558
EINECS
611-907-1

Chemical Properties

Formula
C62H111N11O12
Formula Weight
1202.61
Form
Crystalline solid
Melting point
146-151°
Solubility
Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.

Applications

Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF.Cyclosporin A is used as dermatologic drug to treat rheumatoid arthritis and prevent skin disorders. It acts as an immunosuppressive agent, which suppresses the immune function. It finds application as an anti-asthmatic drug to treat asthma. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

Notes

Store in cool place. Incompatible with alkali metals, aluminum and strong oxidizing agents.

Literature References

Staudinger, L. A.; Spano, S. J.; Lee, W. S.; Coelho, N.; Moriarty, T. J.; McCulloch, C. A. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A. Int. J. Biochem. Cell Biol. 2015, 62, 80-87.

Petrillo, C.; Cesana, D.; Piras, F.; Bartolaccini, S.; Naldini, L.; Montini, E.; Rudnitski, A. K. Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells. Molecular Therapy 2015, 23 (2), 352-362.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H350-H360

Harmful if swallowed. May cause cancer. May damage fertility or the unborn child.

Precautionary Statements: P201-P280-P301+P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2752
Beilstein
3647785
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
GZ4120000

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