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J63191 Cyclosporin A, 99+%

CAS Number
59865-13-3
Synonyms
Cyclosporine A
Antibiotic S 7481F1

Stock No. Size Price ($) Quantity Availability
J63191-03 1g 179.00
J63191-06 5g 396.00
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Cyclosporin A, 99+%

MDL
MFCD00274558
EINECS
611-907-1

Chemical Properties

Formula
C62H111N11O12
Formula Weight
1202.61
Form
Crystalline solid
Melting point
146-151°
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.

Applications

Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF.Cyclosporin A is used as dermatologic drug to treat rheumatoid arthritis and prevent skin disorders. It acts as an immunosuppressive agent, which suppresses the immune function. It finds application as an anti-asthmatic drug to treat asthma. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

Notes

Store in cool place. Incompatible with alkali metals, aluminum and strong oxidizing agents.

Literature References

Staudinger, L. A.; Spano, S. J.; Lee, W. S.; Coelho, N.; Moriarty, T. J.; McCulloch, C. A. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A. Int. J. Biochem. Cell Biol. 2015, 62, 80-87.

Petrillo, C.; Cesana, D.; Piras, F.; Bartolaccini, S.; Naldini, L.; Montini, E.; Rudnitski, A. K. Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells. Molecular Therapy 2015, 23 (2), 352-362.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H350-H360FD

Harmful if swallowed. May cause cancer. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child.

Precautionary Statements: P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2752
Beilstein
3647785
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
GZ4120000

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