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PIPES, is used as a buffering agent in biochemistry. PIPES has pKa near the physiological pH which makes it useful in cell culture work. PIPES has been documented minimizing lipid loss when buffering glutaraldehyde histology in plant and animal tissues.
MJ Alowitz.; MM Scherer. Kinetics of nitrate, nitrite, and Cr (VI) reduction by iron metal. Environmental Science & Technology.2002, 36, (3), 299-306.
JB Olmsted, GG Borisy. Ionic and nucleotide requirements for microtubule polymerization in vitro. Biochemistry. 1975, 14, (13), 2996-3005.