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Isoguvacine·HCl is an agonist of γ-amino butyric acid receptor. Isoguvacine interactions have many similar biochemical features of GABA synaptic function. Isoguvacine·HCl is a specific GABAA receptor agonist. This compound suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
Willian Seiji Korim.; Simon McMullan.; Sergio L. Cravo.; Paul M. Pilowsky. Asymmetrical changes in lumbar sympathetic nerve activity following stimulation of the sciatic nerve in rat. Brain Research. 2011, 1391, 60-70.
Takako Shimidzu.; Yoshinori Itoh.; Michiko Oka.; Tsuyoshi Ishima.; Yojiro Ukai.; Yoshiaki Yoshikuni.; Kiyoshi Kimura. Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: Possible involvement of GABAB receptor up-regulation after repeated treatment. European Journal of Pharmacology. 1997, 338,(3), 225-232.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant