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64603-90-3 - Isoguvacine hydrochloride, 99% - 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride - J63243 - Alfa Aesar

J63243 Isoguvacine hydrochloride, 99%

CAS Number
64603-90-3
Synonyms
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

Size Price ($) Quantity Availability
100mg 341.00
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Isoguvacine hydrochloride, 99%

MDL
MFCD00055192

Chemical Properties

Formula
C6H9NO2•HCl
Formula Weight
163.60
Form
Powder
Solubility
Soluble in water

Applications

Isoguvacine·HCl is an agonist of γ-amino butyric acid receptor. Isoguvacine interactions have many similar biochemical features of GABA synaptic function. Isoguvacine·HCl is a specific GABAA receptor agonist. This compound suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Willian Seiji Korim.; Simon McMullan.; Sergio L. Cravo.; Paul M. Pilowsky. Asymmetrical changes in lumbar sympathetic nerve activity following stimulation of the sciatic nerve in rat. Brain Research. 2011, 1391, 60-70.

Takako Shimidzu.; Yoshinori Itoh.; Michiko Oka.; Tsuyoshi Ishima.; Yojiro Ukai.; Yoshiaki Yoshikuni.; Kiyoshi Kimura. Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: Possible involvement of GABAB receptor up-regulation after repeated treatment. European Journal of Pharmacology. 1997, 338,(3), 225-232.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US5908286

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