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59-33-6 - Pyrilamine maleate - Mepyramine maleate - N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt - J63247 - Alfa Aesar

J63247 Pyrilamine maleate

CAS Number
59-33-6
Synonyms
Mepyramine maleate
N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt

Size Price ($) Quantity Availability
25g 49.20
100g 173.04
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Pyrilamine maleate

MDL
MFCD00069333
EINECS
200-422-7

Chemical Properties

Formula
C17H23N3O.C4H4O4
Formula Weight
401.46
Form
Powder
Solubility
Soluble in water at 100mg/ml

Applications

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Lijinsky, W. Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.Food and Chemical Toxicology.1984, 22, (1), 27-30.

Jang O. Oh.; Charles A. Evans. Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 4880 ?.Virology.1960, 10, (1), 127-143.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7984
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
UT1225000

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