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Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.
Julia Penso.; Rivka Beitner. Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells. European Journal of Pharmacology. 1998, 342, (1), 113-117.
Maurizio Botta.; Federico Corelli.; Francesco Gasparrini.; Flavia Messina.; Claudia Mugnaini. Chiral Azole Derivatives. 4.1 Enantiomers of Bifonazole and Related Antifungal Agents:? Synthesis, Configuration Assignment, and Biological Evaluation. J. Org. Chem. 2000, 65,(15), 4736-4739.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.