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J63255 Indomethacin, 99+%

CAS Number
53-86-1
Synonyms
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Stock No. Size Price ($) Quantity Availability
J63255-03 1g 15.10
J63255-06 5g 43.00
J63255-14 25g 159.00
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Indomethacin, 99+%

MDL
MFCD00057095
EINECS
200-186-5

Chemical Properties

Formula
C19H16ClNO4
Formula Weight
357.80
Form
Powder
Melting point
158-161°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in ethanol and dimethyl sulfoxide.

Applications

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

Notes

Incompatible with strong bases. Light sensitive.

Literature References

Tajiri, T.; Morita, S.; Sakamoto, R.; Mimura, H.; Ozaki, Y.; Reppas, C.; Kitamura, S. Developing dissolution testing methodologies for extended-release oral dosage forms with supersaturating properties. Case example: Solid dispersion matrix of indomethacin. Int. J. Pharm. 2015, 490 (1-2), 368-374.

Thakral, S.; Suryanarayanan, R. Salt formation during freeze-drying - an approach to enhance indomethacin dissolution. Pharm. Res. 2015, 32 (11), 3722-3731.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H317-H360FD

Fatal if swallowed. May cause an allergic skin reaction. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child.

Precautionary Statements: P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,4968
Beilstein
497341
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
NL3500000

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