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53-86-1 - Indomethacin, 99+% - 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid - J63255 - Alfa Aesar

J63255 Indomethacin, 99+%

CAS Number
53-86-1
Synonyms
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Size Price ($) Quantity Availability
1g 14.40
5g 40.90
25g 151.00
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Indomethacin, 99+%

MDL
MFCD00057095
EINECS
200-186-5

Chemical Properties

Formula
C19H16ClNO4
Formula Weight
357.80
Form
Powder
Melting point
158-161°
Sensitivity
Light Sensitive
Solubility
Soluble in ethanol and dimethyl sulfoxide.

Applications

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

Notes

Incompatible with strong bases. Light sensitive.

Literature References

Tajiri, T.; Morita, S.; Sakamoto, R.; Mimura, H.; Ozaki, Y.; Reppas, C.; Kitamura, S. Developing dissolution testing methodologies for extended-release oral dosage forms with supersaturating properties. Case example: Solid dispersion matrix of indomethacin. Int. J. Pharm. 2015, 490 (1-2), 368-374.

Thakral, S.; Suryanarayanan, R. Salt formation during freeze-drying - an approach to enhance indomethacin dissolution. Pharm. Res. 2015, 32 (11), 3722-3731.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H341

Fatal if swallowed. Suspected of causing genetic defects.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4968
Beilstein
497341
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
NL3500000

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