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57265-65-3 - Calmidazolium chloride - J63270 - Alfa Aesar

J63270 Calmidazolium chloride

CAS Number
57265-65-3
Synonyms

Size Price ($) Quantity Availability
10mg 197.76
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Calmidazolium chloride

MDL
MFCD00077679

Chemical Properties

Formula
C31H23Cl7N2O
Formula Weight
687.71
Form
Solid
Solubility
Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.

Applications

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+ transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+ influx distinct from store-operated Ca2+ entry and unaccompanied by Ca2+ store depletion, mobilizing stores and evoking a Ca2+ signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

Notes

Store at -20°C. Incompatible with oxidizing agents and heat.

Literature References

Sandeep Kumar.; Vasundhara Kain.; Sandhya L. Sitasawad. Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis. Free Radical Biology and Medicine. 2009, 47 (6), 699-709 .

Andrew J. Sansom.; Cynthia L. Darlington.; Paul F. Smith.; Darrin P. D. Gilchrist.; Ciandra J. Keenan.; Robert Kenyon. Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs.Experimental Brain Research. 1993, 93 (2),271-278 .

Other References

Harmonized Tariff Code
2933.29
TSCA
No

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