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27848-84-6 - Nicergoline - 5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester - J63295 - Alfa Aesar

J63295 Nicergoline

CAS Number
27848-84-6
Synonyms
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester

Size Price ($) Quantity Availability
100mg 77.10
1g 236.00
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Nicergoline

MDL
MFCD00869626
EINECS
248-694-6

Chemical Properties

Formula
C24H26BrN3O3
Formula Weight
484.39
Form
Powder
Solubility
Soluble in alcohol, chloroform, and acetone. Insoluble in water.

Applications

Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic α1-adrenoceptors on vascular smooth muscle.

Notes

Protect from heat. Store away from oxidizing agents.

Literature References

Arcamone, F.; Glasser, A.G.; Grafnetterov, J.; Minghetti, A.; Nicolella, V. TStudies on the metabolism of ergoline derivatives: Metabolism of nicergoline? in man and in animals.BBiochemical Pharmacology.1972, 21, (16), 2205-2213.

Bengt Winblad.; Mario Fioravanti.; Tomas Dolezal.; Inara Logina.; Ivan Gospodinov Milanov.; Dinu Cristian Popescu.; Alina Solomon. Therapeutic Use of Nicergoline.Clinical Drug Investigation.2008, 28, (9), 533-552.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6496
Harmonized Tariff Code
2939.69
TSCA
No
RTECS
KE6341000

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