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J63361 1,1-Dimethylbiguanide hydrochloride

CAS Number
1115-70-4
Synonyms
Metformin hydrochloride

Stock No. Size Price ($) Quantity Availability
J63361-06 5g 28.50
J63361-14 25g 82.60
J63361-22 100g 242.00
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1,1-Dimethylbiguanide hydrochloride

MDL
MFCD00012582
EINECS
214-230-6

Chemical Properties

Formula
C4H11N5•HCl
Formula Weight
165.62
Form
Powder
Melting point
218-226°
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).

Applications

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Cinquina, A.L.; Longo, F.; Calı?, A.; De Santis, L.; Baccelliere, R.; Cozzani, R.Validation and comparison of analytical methods for the determination of histamine in tuna fish samples. Journal of Chromatography A.2004, 1032, (1-2), 79-85.

Nobuyuki Yasuda.; Takashi Inoue.; Tadashi Nagakura.; Kazuto Yamazaki.; Kazunobu Kira.; Takao Saeki.; Isao Tanaka. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochemical and Biophysical Research Communications.2002, 298, (5), 779-784.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,5938
Harmonized Tariff Code
2925.29
TSCA
No
RTECS
DU1800000

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