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J63383 Thrombin, bovine plasma

CAS Number
9002-04-4
Synonyms
Factor IIa
EC 3.4.21.5

Stock No. Size Price ($) Quantity Availability
J63383-!P 100kilounits 745.00
J63383-!T 500kilounits 2390.00
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Thrombin, bovine plasma

MDL
MFCD00166053
EINECS
232-648-7

Chemical Properties

Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
Reconstitute in 0.9% sodium chloride

Applications

Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus

Notes

Lyophilized from a solution containing glycine, sodium chloride and calcium chloride. Specific activity is in the range of 90-250 NIH units/mg protein

Literature References

Walter Kisiel.; William M. Canfield.; Lowell H. Ericsson.; Earl W. Davie. Anticoagulant properties of bovine plasma protein C following activation by thrombin.Biochemistry.1977, 16, (26), 5824-5831.

Walter Kisiel. Human plasma protein c: isolation, characterization, and mechanism of activation by α-thrombin.J Clin Invest.1979, 64, (3), 761-769..

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H317-H319

Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation.

Precautionary Statements: P264b-P272-P280-P302+P352-P305+P351+P338-P333+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation or rash occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9383
Harmonized Tariff Code
3507.90
TSCA
Yes
RTECS
XO8950000

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