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Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus
Walter Kisiel.; William M. Canfield.; Lowell H. Ericsson.; Earl W. Davie. Anticoagulant properties of bovine plasma protein C following activation by thrombin.Biochemistry.1977, 16, (26), 5824-5831.
Walter Kisiel. Human plasma protein c: isolation, characterization, and mechanism of activation by α-thrombin.J Clin Invest.1979, 64, (3), 761-769..
Hazard Statements: H315-H317-H319
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation.
Precautionary Statements: P264b-P272-P280-P302+P352-P305+P351+P338-P333+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation or rash occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant