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30562-34-6 - Geldanamycin, 99+% - NSC 122750 - U-29135 - J63397 - Alfa Aesar

J63397 Geldanamycin, 99+%

CAS Number
30562-34-6
Synonyms
NSC 122750
U-29135

Size Price ($) Quantity Availability
25mg 144.00
100mg 292.00
250mg 375.00
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Geldanamycin, 99+%

MDL
MFCD00274570

Chemical Properties

Formula
C29H40N2O9
Formula Weight
560.64
Form
Powder
Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Applications

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Notes

Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.

Literature References

S. Mark Roe.; Chrisostomos Prodromou.; Ronan O'Brien.; John E. Ladbury.; Peter W. Piper.; Laurence H. Pearl. Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin.J. Med. Chem. 1999, 42 (2),260-266 .

GHS Hazard and Precautionary Statements

Hazard Statements: H303

May be harmful if swallowed.

Precautionary Statements: P312a

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
LX8920000

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