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Substance P is used as a neurokinin NK-1 receptor agonist, neurokinin undecapeptide neurotransmitter and neuromodulator, also used in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2.
Fred Lembeck.; Peter Holzer. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation.Naunyn-Schmiedeberg's Archives of Pharmacology.1979, (2), 175-183.
Lee, Y.; Takami, K.; Kawai, Y.; Girgis, S.; Hillyard, C.J.; MacIntyre, I.; Emson, P.C.; Tohyama, M. Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.Neuroscience.1985, (4), 1227-1237.