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10540-29-1 - Tamoxifen, 98% - cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene - J63509 - Alfa Aesar

J63509 Tamoxifen, 98%

CAS Number
10540-29-1
Synonyms
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

Size Price ($) Quantity Availability
500mg 84.50
1g 143.00
5g 632.00
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Tamoxifen, 98%

MDL
MFCD00010454
EINECS
234-118-0

Chemical Properties

Formula
C26H29NO
Formula Weight
371.52
Form
Powder
Solubility
Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.

Applications

Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

Notes

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.

Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.

GHS Hazard and Precautionary Statements

Hazard Statements: H350-H360-H362

May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.

Precautionary Statements: P263-P260-P201-P281-P264-P270-P202-P308+P313-P405-P501a

Avoid contact during pregnancy/while nursing. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9048
Harmonized Tariff Code
2922.29
TSCA
No
RTECS
KR5919600

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