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J63509 Tamoxifen, 98%

CAS Number
10540-29-1
Synonyms
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

Stock No. Size Price ($) Quantity Availability
J63509-ME 500mg 94.80
J63509-03 1g 160.00
J63509-06 5g 675.00
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Tamoxifen, 98%

MDL
MFCD00010454
EINECS
234-118-0

Chemical Properties

Formula
C26H29NO
Formula Weight
371.52
Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.

Applications

Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

Notes

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.

Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H350-H360FD-H362

Harmful if swallowed. May cause cancer. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child. May cause harm to breast-fed children.

Precautionary Statements: P201-P202-P260-P263-P264b-P270-P281-P301+P312-P308+P313-P330-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid contact during pregnancy/while nursing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9048
Harmonized Tariff Code
2922.29
TSCA
No
RTECS
KR5919600

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