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103745-39-7 - Fasudil, 98+% - HA-1077 - J63525 - Alfa Aesar

J63525 Fasudil, 98+%

CAS Number
103745-39-7
Synonyms
HA-1077

Size Price ($) Quantity Availability
10mg 139.05
50mg 479.20
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Fasudil, 98+%

MDL
MFCD00866182

Chemical Properties

Formula
C14H17N3O2S
Formula Weight
327.83
Form
Crystalline powder
Solubility
Soluble in water or DMSO

Applications

HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Literature References

Wickman, G., C. Lan.; and B. Vollrath. Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm. Circ Res. 201292 (7), 809-16.

Other References

Merck
14,3942
Harmonized Tariff Code
2935.00
TSCA
No

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