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54143-56-5 - Flecainide acetate, 98% - N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt - J63527 - Alfa Aesar

J63527 Flecainide acetate, 98%

CAS Number
54143-56-5
Synonyms
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt

Size Price ($) Quantity Availability
100mg 219.39
1g 660.23
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Flecainide acetate, 98%

MDL
MFCD00214290
EINECS
258-997-5

Chemical Properties

Formula
C17H20F6N2O3.C2H4O2
Formula Weight
474.40
Form
Powder
Melting point
145-147°
Solubility
Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.

Applications

Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.

Notes

Incompatible with oxidizing agents and heat.

Literature References

Doki, K.; Sekiguchi, Y.; Keisuke Kuga, K.; Aonuma, K.; Homma, M.Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity. Drug Metab. Pharmacokinet. 2015, 30 (4), 257-262.

Moffett, B. S.; Valdes, S. O.; Lupo, P. J.; delaUz, C.; Miyake, C.; Krenek, M.; Kim, J. J. Flecainide Use in Children with Cardiomyopathy or Structural Heart Disease. Pediatr. Cardiol. 2015, 36 (1), 146-150.

GHS Hazard and Precautionary Statements

Hazard Statements: H361-H302-H315-H319-H335

Suspected of damaging fertility or the unborn child. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P301+P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4098
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
CV5792550

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