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104987-11-3 - Tacrolimus, 99+% - FK-506 - Fugimycin - J63571 - Alfa Aesar

J63571 Tacrolimus, 99+%

CAS Number
104987-11-3
Synonyms
FK-506
Fugimycin

Size Price ($) Quantity Availability
50mg 155.53
100mg 255.44
500mg 525.64
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Tacrolimus, 99+%

MDL
MFCD11045918

Chemical Properties

Formula
C44H69NO12
Formula Weight
804.02
Form
Powder
Melting point
120-125°
Solubility
Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.

Applications

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. It is also used in the treatment of other T cell-mediated diseases such as eczema, Kimura's disease and Cushing's syndrome. Further, it is used as a research tool in chemically induced dimerization applications. In addition, it is used in liver transplantation and to suppress the inflammation in ulcerative cells. In dermatology, it is used as an ointment to treat eczema especially atopic dermatitis.

Notes

Incompatible with strong oxidizing agents.

Literature References

Chapron, B.; Risler, L.; Phillips, B.; Collins, C.; Thummel, K.; Shen, D. Reversible, Time-Dependent Inhibition of CYP3A-Mediated Metabolism of Midazolam and Tacrolimus by Telaprevir in Human Liver Microsomes. J. Pharm. Pharm. Sci. International 2015, 18 (1), 101-111.

Staatz, C. E.; Tett, S. E. Clinical pharmacokinetics of once-daily tacrolimus in solid-organ transplant patients. Clin Pharmacokinet 2015, 54 (10), 993-1025.

GHS Hazard and Precautionary Statements

Hazard Statements: H301

Toxic if swallowed.

Precautionary Statements: P264-P270-P301+P310-P321-P330-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9025
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
KD4200000

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