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J63598 Vinblastine sulfate, 98%

CAS Number
143-67-9
Synonyms
Vincaleukblastine sulfate

Stock No. Size Price ($) Quantity Availability
J63598-MA 10mg 97.80
J63598-MF 50mg 369.00
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Vinblastine sulfate, 98%

MDL
MFCD00082457
EINECS
205-606-0

Chemical Properties

Formula
C46H60N4O13S
Formula Weight
909.06
Form
Powder
Melting point
267°
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in water and dimethylsulfoxide. Insoluble in ethanol.

Applications

Anticancer agent; microtubule disrupter; Induces apoptosis.Vinblastine sulfate is therapeutically used as an antineoplastic. It is also used in the treatment of Hodgkin disease, choriocarcinoma, acute and chronic leukemias.

Notes

Store in a cool place. Hygroscopic. Incompatible with strong oxidizing agents and strong bases.

Literature References

Lee, C. T.; Huang, Y. W.; Yang, C. H.; Huang, K. S. Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids. Curr. Top. Med. Chem. 2015, 15 (15), 1491-1500.

Chen, Q.; Bian, Y.; Zeng, S. Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells. Drug Metab. Pharmacokinet. 2014, 29 (2), 223-226.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H318-H335-H341-H361

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P202-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P330-P332+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9982
Beilstein
3659812
Harmonized Tariff Code
2939.80
TSCA
No
RTECS
YY8400000

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