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143-67-9 - Vinblastine sulfate, 98% - Vincaleukblastine sulfate - J63598 - Alfa Aesar

J63598 Vinblastine sulfate, 98%

CAS Number
143-67-9
Synonyms
Vincaleukblastine sulfate

Size Price ($) Quantity Availability
10mg 94.50
50mg 426.00
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Vinblastine sulfate, 98%

MDL
MFCD00082457
EINECS
205-606-0

Chemical Properties

Formula
C46H60N4O13S
Formula Weight
909.06
Form
Powder
Melting point
267°
Solubility
Soluble in water and dimethylsulfoxide. Insoluble in ethanol.

Applications

Anticancer agent; microtubule disrupter; Induces apoptosis.Vinblastine sulfate is therapeutically used as an antineoplastic. It is also used in the treatment of Hodgkin disease, choriocarcinoma, acute and chronic leukemias.

Notes

Store in a cool place. Hygroscopic. Incompatible with strong oxidizing agents and strong bases.

Literature References

Lee, C. T.; Huang, Y. W.; Yang, C. H.; Huang, K. S. Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids. Curr. Top. Med. Chem. 2015, 15 (15), 1491-1500.

Chen, Q.; Bian, Y.; Zeng, S. Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells. Drug Metab. Pharmacokinet. 2014, 29 (2), 223-226.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P310a-P301+P312a-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9982
Beilstein
3659812
Harmonized Tariff Code
2939.80
TSCA
No
RTECS
YY8400000

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