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Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
Hande, K.R. Etoposide: four decades of development of a topoisomerase II inhibitor.European Journal of Cancer.1998, (10), 1514-1521.
Maurice L. Slevin. The clinical pharmacology of etoposide.Supplement: Recent Advances in Etoposide Therapy Combined Proceedings of Two Symposia.1991, (1), 319-329.
Hazard Statements: H302-H350
Harmful if swallowed. May cause cancer.
Precautionary Statements: P201-P280-P301+P312a-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.