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33419-42-0 - Etoposide - J63651 - Alfa Aesar

J63651 Etoposide

CAS Number
33419-42-0
Synonyms

Size Price ($) Quantity Availability
25mg 51.19
100mg 126.69
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Etoposide

MDL
MFCD00869325
EINECS
251-509-1

Chemical Properties

Formula
C29H32O13
Formula Weight
588.56
Form
Powder
Melting point
236-251°
Solubility
Insoluble in water.

Applications

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Notes

Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.

Literature References

Hande, K.R. Etoposide: four decades of development of a topoisomerase II inhibitor.European Journal of Cancer.1998, (10), 1514-1521.

Maurice L. Slevin. The clinical pharmacology of etoposide.Supplement: Recent Advances in Etoposide Therapy Combined Proceedings of Two Symposia.1991, (1), 319-329.

GHS Hazard and Precautionary Statements

Hazard Statements: H350-H302

May cause cancer. Harmful if swallowed.

Precautionary Statements: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3886
Harmonized Tariff Code
2938.90
TSCA
No
RTECS
KC0190000

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