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58-54-8 - Ethacrynic acid - (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid - J63684 - Alfa Aesar

J63684 Ethacrynic acid

CAS Number
58-54-8
Synonyms
(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

Size Price ($) Quantity Availability
1g 67.98
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Ethacrynic acid

MDL
MFCD00056693
EINECS
200-384-1

Chemical Properties

Formula
C13H12Cl2O4
Formula Weight
303.14
Form
Crystalline powder
Solubility
Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.

Applications

Ethacrynic acid is used to inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Maurice Burg.; Nordica Green. Effect of ethacrynic acid on the thick ascending limb of Henle's loop. Kidney International. 1973, 4, 301-308.

Sanjay Awasthi.; Sanjay K. Srivastava.; Faiyaz Ahmad.; Hassan Ahmad.; Ansari, G.A.S. Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1993, 1164, (2), 173-178.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3717
Harmonized Tariff Code
2918.99
TSCA
No
RTECS
AG6600000

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