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303-45-7 - Gossypol, 98+% - Thespesin - 2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) - J63767 - Alfa Aesar

J63767 Gossypol, 98+%

CAS Number
303-45-7
Synonyms
Thespesin
2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)

Size Price ($) Quantity Availability
100mg 138.00
250mg 270.00
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Gossypol, 98+%

MDL
MFCD00017352

Chemical Properties

Formula
C30H30O8
Formula Weight
518.56
Form
Powder
Solubility
Soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water. Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties.

Applications

Gossypol acts as an inhibitor for several dehydrogenase enzymes. Gossypol has also long been known to possess antimalarial properties. Gossypol provided reliable contraception. gossypol provokes infertility and causes spermatogenesis. Gossypol is used as an active antifertility agent in a variety of male animals, including mice, rats, hamsters, monkeys, rabbits, and bulls.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

M.C. Chang,; Zhiping Gu (Chi-ping Ku),; S.K. Saksena. Effects of Gossypol on the fertility of male rats, hamsters and rabbits. Contraception. 1980, 21(5), 461-469.

Ying-Bo Mao,; Wen-Juan Cai,; Jia-Wei Wang,; Gao-Jie Hong. Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypo. Nature Biotechnology. 2007 , 251307 - 1313 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H341-H361

Harmful if swallowed. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P280-P301+P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4528
Harmonized Tariff Code
2912.49
TSCA
No
RTECS
DU3100000

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