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J63772 Sotalol hydrochloride, 98%

CAS Number
959-24-0
Synonyms
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

Stock No. Size Price ($) Quantity Availability
J63772-MC 100mg 57.30
J63772-03 1g 441.00
J63772-06 5g 731.00
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Sotalol hydrochloride, 98%

MDL
MFCD00242937
EINECS
213-496-0

Chemical Properties

Formula
C12H20N2O3S•HCl
Formula Weight
308.82
Form
Crystalline powder
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.

Applications

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 µM.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Ward, D.E.; Camm, A.J.; Spurrell, A.J. The acute cardiac electrophysiological effects of intravenous sotalol hydrochloride. Clinical Cardiology. 1979, 2, (3), 185-191.

Axel Alt.; Henrike Potthast.; Juergen Moessinger.; Barbara Sickmüller.; Helga Oeser. Biopharmaceutical characterization of sotalol-containing oral immediate release drug products. Clinical Cardiology. 2004, 58, (1), 145-150.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,8728
Harmonized Tariff Code
2935.90
TSCA
No
RTECS
PB0826000

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