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Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 µM.
Ward, D.E.; Camm, A.J.; Spurrell, A.J. The acute cardiac electrophysiological effects of intravenous sotalol hydrochloride. Clinical Cardiology. 1979, 2, (3), 185-191.
Axel Alt.; Henrike Potthast.; Juergen Moessinger.; Barbara Sickmüller.; Helga Oeser. Biopharmaceutical characterization of sotalol-containing oral immediate release drug products. Clinical Cardiology. 2004, 58, (1), 145-150.
Hazard Statements: H303-H315-H319-H335
May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.