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959-24-0 - Sotalol hydrochloride, 98% - N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride - J63772 - Alfa Aesar

J63772 Sotalol hydrochloride, 98%

CAS Number
959-24-0
Synonyms
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

Size Price ($) Quantity Availability
100mg 54.00
1g 432.00
5g 716.00
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Sotalol hydrochloride, 98%

MDL
MFCD00242937
EINECS
213-496-0

Chemical Properties

Formula
C12H20N2O3S•HCl
Formula Weight
308.82
Form
Crystalline powder
Solubility
Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.

Applications

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 µM.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Ward, D.E.; Camm, A.J.; Spurrell, A.J. The acute cardiac electrophysiological effects of intravenous sotalol hydrochloride. Clinical Cardiology. 1979, 2, (3), 185-191.

Axel Alt.; Henrike Potthast.; Juergen Moessinger.; Barbara Sickmüller.; Helga Oeser. Biopharmaceutical characterization of sotalol-containing oral immediate release drug products. Clinical Cardiology. 2004, 58, (1), 145-150.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H303

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8728
Harmonized Tariff Code
2935.00
TSCA
No
RTECS
PB0826000

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