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9015-73-0 - Diethylaminoethyl dextran - DEAE-Dextran - J63781 - Alfa Aesar

J63781 Diethylaminoethyl dextran

CAS Number
9015-73-0
Synonyms
DEAE-Dextran

Size Price ($) Quantity Availability
25g 47.80
100g 153.00
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Diethylaminoethyl dextran

MDL
MFCD00081561

Chemical Properties

Form
Powder
Solubility
Soluble in water.

Applications

DEAE-Dextran is used in the development of sustained release protein delivery and nucleic acid transfection systems. The use of DEAE-Dextran as an efficient adjuvant in vaccine production is well established. For instance, DEAE-Dextran has been used for immunization of guinea pigs and swine with inactivated foot-and-mouth disease and rhesus monkeys with inactivated Venezulean equine encephalomyelitis virus, IVEE. The mechanism of action of DEAE-Dextran is not clear. The effect on the humoral response of rhesus monkeys to IVEE vaccine results in a typical IgM-IgG response. It has been speculated that DEAE-Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

James H. McCutchan,; Joseph S. Pagano. Enhancement of the Infectivity of Simian Virus 40 Deoxyribonucleic Acid With Diethylaminoethyl-Dextran2. J Natl Cancer Inst. 1968, 41 (2),351-357..

H Duc-Nguyen. Enhancing effect of diethylaminoethyl-dextran on the focus-forming titer of a murine sarcoma virus (Harvey strain). J Virol. 1968, 2 (6), 643-644.

Other References

Merck
14,2936
Harmonized Tariff Code
3913.90
TSCA
No
RTECS
HH9250000

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