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59588-86-2 - Alamethicin - U-22324 - J63829 - Alfa Aesar

J63829 Alamethicin

CAS Number
59588-86-2
Synonyms
U-22324

Size Price ($) Quantity Availability
1mg 97.95
5mg 397.58
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Alamethicin

MDL
MFCD00151517

Chemical Properties

Formula
C92H150N22O25
Formula Weight
1964.40
Form
Powder
Melting point
267-270°
Solubility
Soluble in DMSO and ethanol.

Applications

Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.

Notes

Protect from heat. Store away from oxidizing agents.

Literature References

Bechinger, B. Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin. The Journal of Membrane Biology. 1997, 156, (3), 197 -211.

Gordon, L.G.M.; Haydon, D.A. The unit conductance channel of alamethicin. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1972, 255, (3), 1014-1018.

GHS Hazard and Precautionary Statements

Hazard Statements: H301

Toxic if swallowed.

Precautionary Statements: P264-P270-P301+P310-P321-P330-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
AY1900000

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