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23593-75-1 - Clotrimazole - 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole - 1-(o-Chlorotrityl)imidazole - J63895 - Alfa Aesar

J63895 Clotrimazole

CAS Number
23593-75-1
Synonyms
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
1-(o-Chlorotrityl)imidazole

Size Price ($) Quantity Availability
5g 59.84
25g 153.60
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Clotrimazole

MDL
MFCD00057220
EINECS
245-764-8

Chemical Properties

Formula
C22H17ClN2
Formula Weight
344.84
Form
Powder
Melting point
141-149°
Solubility
Soluble in chloroform, DMSO, DMF and alcohols

Applications

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Notes

Store at room temperature. Incompatible with oxidizing agents.

Literature References

E.B Souto.; b, S.A Wissing.; C.M Barbosa.; R.H Müller. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.Int. J. Pharm. 2004, 278 (1),71-77 .

Jack D. Sobel.; Doris Brooker.; Gary E. Stein.; Jessica L. Thomason.; Daniel P. Wermeling.; Blake Bradley.; Louis Weinstein. Single oral dose fluconazole compared with conventional clotrimazole topical therapy of Candida vaginitis.American Journal of Obstetrics and Gynecology. 1995, 172 (4),1263-1268 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P270-P305+P351+P338-P362-P301+P312-P321-P332+P313-P337+P313-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2417
Harmonized Tariff Code
2933.29
TSCA
No
RTECS
NI4377000

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