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16561-29-8 - Phorbol 12-myristate 13-acetate, 99+% - PMA - TPA - J63916 - Alfa Aesar

J63916 Phorbol 12-myristate 13-acetate, 99+%

CAS Number
16561-29-8
Synonyms
PMA
TPA

Size Price ($) Quantity Availability
1mg 45.34
5mg 166.00
10mg 254.96
25mg 481.56
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Phorbol 12-myristate 13-acetate, 99+%

MDL
MFCD00036736

Chemical Properties

Formula
C36H56O8
Formula Weight
616.83
Form
Film or powder
Sensitivity
Light Sensitive
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Applications

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Notes

Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Vicentini, L.M.; Di Virgilio, F.; Ambrosini, A.; Pozzan, T.; Meldolesi, J. Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells. Biochemical and Biophysical Research Communications. 1985, 127, (1), 310-317.

Emerit, I.; Cerutti, P.A. Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes. Current Issue. 1982, 79, (23), 7509-7513.

GHS Hazard and Precautionary Statements

Hazard Statements: H315

Causes skin irritation.

Precautionary Statements: P280-P264-P362-P321-P332+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water.

Other References

Merck
14,7332
Beilstein
2407201
Harmonized Tariff Code
2915.90
TSCA
No
RTECS
QH4377000

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