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19545-26-7 - Wortmannin, Penicillium funiculosum, 99+% - KY 12420 - J63983 - Alfa Aesar

J63983 Wortmannin, Penicillium funiculosum, 99+%

CAS Number
19545-26-7
Synonyms
KY 12420

Size Price ($) Quantity Availability
10mg 113.30
25mg 214.20
50mg 402.30
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Wortmannin, Penicillium funiculosum, 99+%

MDL
MFCD00133927

Chemical Properties

Formula
C23H24O8
Formula Weight
428.44
Form
Powder
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO, ethanol, methanol, and DMF.

Applications

Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Notes

Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Mantle, P.G. Secondary Metabolites of Penicillium and Acremonium. Penicillium and Acremonium. 1987, 1, 161-243.

Walter Haefliger.; Daniel Hauser. Isolierung und Strukturaufklärung von 11-Desacetoxy-wortmannin. Helvetica Chimica Acta. 1973, 56, (8), 2901-2904.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.

Precautionary Statements: P260-P284-P301+P310-P304+P340-P320-P330-P361-P302+P350-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,10053
Beilstein
67676
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
CB9641000

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