Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.
Mantle, P.G. Secondary Metabolites of Penicillium and Acremonium. Penicillium and Acremonium. 1987, 1, 161-243.
Walter Haefliger.; Daniel Hauser. Isolierung und Strukturaufklärung von 11-Desacetoxy-wortmannin. Helvetica Chimica Acta. 1973, 56, (8), 2901-2904.
Hazard Statements: H300-H310-H330
Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.
Precautionary Statements: P260-P201-P280h-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.