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67-73-2 - Fluocinolone acetonide - 6-alpha-Fluorotriamcinolone acetonide - J63996 - Alfa Aesar

J63996 Fluocinolone acetonide

CAS Number
67-73-2
Synonyms
6-alpha-Fluorotriamcinolone acetonide

Size Price ($) Quantity Availability
100mg 48.60
1g 266.00
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Fluocinolone acetonide

MDL
MFCD00010525
EINECS
200-668-5

Chemical Properties

Formula
C24H30F2O6
Formula Weight
452.49
Form
Crystalline powder
Melting point
267-269°
Solubility
Soluble in water (partly), DMSO, alcohol, chloroform and methanol.

Applications

Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Glenn J.Jaffe, MD; Joshua Ben-nun, MD; Hong Guo, PhD; James P.Dunn, MD; Paul Ashton, PhD. Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology. 2000, 107,(11), 2024-2033.

 

B.J.Poulsen; E.Young; V.Coquilla; M.Katz. Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester. Journal of Pharmaceutical Sciences. 1968, 57,(6), 928-933.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4150
Harmonized Tariff Code
2937.22
TSCA
No
RTECS
TU3830000

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