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J64000 Doxorubicin hydrochloride

CAS Number
25316-40-9
Synonyms
14-Hydroxydaunomycin

Stock No. Size Price ($) Quantity Availability
J64000-MA 10mg 181.00
J64000-MF 50mg 392.00
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Doxorubicin hydrochloride

MDL
MFCD00077757
EINECS
246-818-3

Chemical Properties

Formula
C27H29NO11•HCl
Formula Weight
579.99
Form
Solid
Melting point
216° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water.

Applications

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

Notes

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

Benival, D. M.; Devarajan, P. V. In Situ Lipidization as a New Approach for the Design of a Self Microemulsifying Drug Delivery System (SMEDDS) of Doxorubicin Hydrochloride for Oral Administration. J. Biomed. Nanotechnol. 2015, 11 (5), 913-922.

Esmaeili, A.; Hadad, N. A. Preparation of ZnFe2O4-chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics. Ceram. Int. 2015, 41 (6), 7529-7535.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H318-H335-H340-H350-H361fd

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause genetic defects. May cause cancer. Suspected of damaging fertility. Suspected of damaging the unborn child.

Precautionary Statements: P201-P202-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P330-P332+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3439
Beilstein
4229251
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
QI9295900

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