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J64028 Tamibarotene

CAS Number
94497-51-5
Synonyms
AM 80

Stock No. Size Price ($) Quantity Availability
J64028-MA 10mg 110.00
J64028-MF 50mg 490.00
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Tamibarotene

MDL
MFCD00866188

Chemical Properties

Formula
C22H25NO3
Formula Weight
351.44
Form
Solid
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble to 50 mM in DMSO

Applications

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

B.A.Bernard; J.M.Bernardon; C.Delescluse; B.Martin; M.C.Lenoir; J.Maignan; B.Charpentier; W.R.Pilgrim; U.Reichert; B.Shroot. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992, 186,(2), 977-983.

 

Shiro Jimi; Kota Mashima; Taichi Matsumoto; Shuji Hara; Junji Suzumiya; Kazuo Tamura. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. International Journal of Oncology. 2007, 31,(2), 397-404.

Other References

Merck
14,9047
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
DH6940000

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