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N-Acetyl-Arg-Glu-Lys-Arg-7-amino-4-(trifluoromethyl)coumarin - Ac-REKR-AFC - Ac-Arg-Glu-Lys-Arg-AFC - J64106 - Alfa Aesar

J64106 N-Acetyl-Arg-Glu-Lys-Arg-7-amino-4-(trifluoromethyl)coumarin

CAS Number
Synonyms
Ac-REKR-AFC
Ac-Arg-Glu-Lys-Arg-AFC

Size Price ($) Quantity Availability
10mg 222.00
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N-Acetyl-Arg-Glu-Lys-Arg-7-amino-4-(trifluoromethyl)coumarin

MDL
MFCD03452896

Chemical Properties

Formula
C35H51F3N12O9
Formula Weight
840.80
Form
Solid
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO or DMF.

Applications

N-Acetyl-Arg-Glu-Lys-Arg-7-amino-4-(trifluoromethyl)coumarin is employed as a fluorogenic cathepsin D substrate.

Notes

When Ac-REKR-AFC is hydrolyzed, the free AFC can be measured by fluorescence (400nm excitation, 505nm emission) or spectrophotometry (extinction coefficient 12,600 at 380nm, pH 7.2).

Literature References

Micky D.Tortorella; Elizabeth C.Arner; Robert Hills; Jennifer Gormley; Kam Fok; Lyle Pegg; Grace Munie; Anne-Marie Malfait. ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms. Archives of Biochemistry and Biophysics. 2005, 444,(1), 34-44.

 

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2932.20
TSCA
No

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