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Azadibenzocyclooctyne-NHS ester, with 4 carbon linker - ADIBO-NHS ester, with 4 carbon linker - J64128 - Alfa Aesar

J64128 Azadibenzocyclooctyne-NHS ester, with 4 carbon linker

CAS Number
Synonyms
ADIBO-NHS ester, with 4 carbon linker

Size Price ($) Quantity Availability
25mg 134.00
100mg 416.00
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Azadibenzocyclooctyne-NHS ester, with 4 carbon linker

Chemical Properties

Formula
C23H18N2O5
Formula Weight
402.40
Form
Solid
Sensitivity
Moisture Sensitive
Solubility
Soluble in dimethyl formamide, terahydrofuran, dimethyl sulfocide and dichloromethane.

Applications

Azadibenzocyclooctyne-NHS ester, with 4 carbon linker is used in various applications like protein-peptide conjugates, antibody-enzyme or antibody-drug conjugates, protein or peptide-oligonucleotide conjugates and surface modification. It is used to introduce cyclooctyne moiety in to biomolecules and amine containing compounds.

Notes

Moisture and heat sensitive. Store in cool place. Incompatible with strong oxidizng agents.

Literature References

Jeon, J.; Kang, J. A.; Shim, H. E.; Nam, Y. R.; Yoon, S.; Kim, H. R.; Lee, D. E.; Park, S. H. Efficient method for iodine radioisotope labeling of cyclooctyne-containing molecules using strain-promoted copper-free click reaction. Bioorg. Med. Chem. 2015, 23 (13), 3303-3308.

Mammen, L.; Bley, K.; Papadopoulos, P.; Schellenberger, F.; Encinas, N.; Butt, H. J.; Weiss, C. K.; Vollmer, D. Functional superhydrophobic surfaces made of Janus micropillars. Soft Matter 2015, 11, 506-515.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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