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Azadibenzocyclooctyne-NHS ester, with 4 carbon linker is used in various applications like protein-peptide conjugates, antibody-enzyme or antibody-drug conjugates, protein or peptide-oligonucleotide conjugates and surface modification. It is used to introduce cyclooctyne moiety in to biomolecules and amine containing compounds.
Jeon, J.; Kang, J. A.; Shim, H. E.; Nam, Y. R.; Yoon, S.; Kim, H. R.; Lee, D. E.; Park, S. H. Efficient method for iodine radioisotope labeling of cyclooctyne-containing molecules using strain-promoted copper-free click reaction. Bioorg. Med. Chem. 2015, 23 (13), 3303-3308.
Mammen, L.; Bley, K.; Papadopoulos, P.; Schellenberger, F.; Encinas, N.; Butt, H. J.; Weiss, C. K.; Vollmer, D. Functional superhydrophobic surfaces made of Janus micropillars. Soft Matter 2015, 11, 506-515.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant