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320-67-2 - 5-Azacytidine, 98% - 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one - Ladakamycin - J64159 - Alfa Aesar

J64159 5-Azacytidine, 98%

CAS Number
320-67-2
Synonyms
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
Ladakamycin

Size Price ($) Quantity Availability
1g 53.60
5g 214.00
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5-Azacytidine, 98%

MDL
MFCD00006539
EINECS
206-280-2

Chemical Properties

Formula
C8H12N4O5
Formula Weight
244.2
Form
Powder
Melting point
226-232° dec.
Solubility
Soluble in water.

Applications

5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

Siva P. Kumpatla.; Timothy C. Hall. Longevity of 5-azacytidine-mediated gene expression and re-establishment of silencing in transgenic rice. Plant Molecular Biology. 1998, 38, (6), 1113-1122.

Sunil Rangappa.; Chen Fen.; Eng Hin Lee.; Ariff Bongso.; Eugene Sim Kwang Wei. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. The Annals of Thoracic Surgery. 2003, 75, (3), 775-779.

GHS Hazard and Precautionary Statements

Hazard Statements: H340-H350-H302

May cause genetic defects. May cause cancer. Harmful if swallowed.

Precautionary Statements: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,890
Beilstein
620461
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
XZ3017500

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