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Cytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation.
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S.Warach, MD, PhD; L.Creed Pettigrew, MD; J.F.Dashe, MD, PhD; P.Pullicino MD; David M.Lefkowitz, MD; L.Sabounjian, RN; K.Harnett, MS; U.Schwiderski, PhD; R.Gammans, PhD. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Annals of Neurology. 2000, 48,(5), 713-722.