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Oxidized LDL induces foam cell formation in some macrophage cell lines. Research on foam cell formation is relevant to the study of atherosclerosis. Cellular exposure to ox-LDL results is the formation of lipid droplets containing cholesteryl esters in the cytoplasm of the macrophage as the lipoprotein particles are metabolized by the cell.Lipoprotein, low density, oxidized, human plasma, Low-TBAR is used as a marker in atherosclerosis research and marker for oxidative stress.
Huang, B.; Jin, M.; Yan, H.; Cheng, Y.; Huang, D.; Ying, S.; Zhang, L. Simvastatin enhances oxidized?low density lipoprotein?induced macrophage autophagy and attenuates lipid aggregation. Mol. Med. Rep. 2015, 11 (2), 1093-1098.
Orsó, E.; Matysik, S.; Grandl, M.; Liebisch, G.; Schmitz, G. Human native, enzymatically modified and oxidized low density lipoproteins show different lipidomic pattern. Biochim. Biophys. Acta 2015, 1851 (3), 299-306.