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Bax Channel Blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 M). It is suggested to inhibit Bax (Bcl-2-associated X protein) channel formation and activity.
Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax Channel Modulation. J. Med. Chem. 2003, 46,(21), 4365-4368.
Elisabete Ferreiro; Catarina R.Oliveira; Claudia M.F.Pereira. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiology of Disease. 2008, 30,(3), 331-342.
Hazard Statements: H341
Suspected of causing genetic defects.
Precautionary Statements: P201-P202-P281-P308+P313-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant