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J64257 Bax Channel Blocker

CAS Number
335165-69-0
Synonyms
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol bis(trifluoracetate) salt

Stock No. Size Price ($) Quantity Availability
J64257-MA 10mg 144.00
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Bax Channel Blocker

MDL
MFCD09037523

Chemical Properties

Formula
C19H21Br2N3O•2CF3CO2H
Formula Weight
695.24
Form
Powder
Storage & Sensitivity
Keep Cold. Hygroscopic. Light Sensitive. Store under Nitrogen.
Solubility
Soluble in water at 5mM or in DMSO at 100mM

Applications

Bax Channel Blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 M). It is suggested to inhibit Bax (Bcl-2-associated X protein) channel formation and activity.

Notes

Light sensitive and hygroscopic. Incompatible with oxidizing agents and heat.

Literature References

Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax Channel Modulation. J. Med. Chem. 2003, 46,(21), 4365-4368.

 

Elisabete Ferreiro; Catarina R.Oliveira; Claudia M.F.Pereira. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiology of Disease. 2008, 30,(3), 331-342.

GHS Hazard and Precautionary Statements

Hazard Statements: H341

Suspected of causing genetic defects.

Precautionary Statements: P201-P202-P281-P308+P313-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.59
TSCA
No

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